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Test Code: LABG6PDF
Description And Clinical Indication: G6PD, 6-PGD, 6-PGD/G6PD Ratio

Glucose-6-Phosphate Dehydrogenase deficiency (G6PD) is an X-linked disorder.  Females who are carriers can have low levels of G6PD activity. However, since women have another normal X chromosome, G6PD activity can be in the normal range thereby obscuring the detection of the carrier state.  In view of assay procedure which includes testing of 6-Phopshogluconate Dehydrogenase (6PGD), a ratio of 6PGD to G6PD activity has become a useful screen for recognizing G6PD carrier status in females.  The normal ratio of 6PGD to G6PD is less than or equal to 0.8.  The ratio found in G6PD deficient carriers is greater than or equal to 1.0.


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