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Test Code: HPVPCR
Description: High-risk Human Papilloma Viruses (HPVs) are the etiologic agents of many squamous cell carcinomas, including those of the uterine cervix. In particular, HPV 16 and HPV 18 show increased capacity to induce malignant transformation and are the most common HPV types found in squamous cell carcinomas of the oropharynx and anal canal. Detection of HPV 16 and/or 18 in paraffin-embedded tissues may be useful in several clinical settings: 1) to help distinguish reactive/atrophic changes from dysplasia; 2) as an independent positive prognostic factor for patients with oropharyngeal squamous cell carcinoma (OPSCC); 3) potentially, to guide the use of alternative therapeutic regimens for OPSCC. The assay to identify HPV 16 and HPV 18 includes isolation of DNA followed by a multiplex, real-time polymerase chain reaction that detects and distinguishes between these two high-risk HPV types.


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