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PAROXYSMAL NOCTURNAL HEMOGLOBINURIA SCREEN (PNH) SCREEN PATH13/FCPATH

Test Code: PATH13/FCPATH
Description: This assay detects loss of glycosyl phosphatidylinositol (GPI)-anchored proteins on erythrocytes and neutrophils, and is of diagnostic utility in suspected cases of paroxysmal nocturnal hemoglobinuria (PNH). Glycophorin and CD15 are used to assist in gating erythrocytes and neutrophils, respectively. Expression of CD55, CD59, FLAER, CD14, CD15, CD24, CD33 and CD45CD16, and CD66b is are analyzed, with the goal of detecting and quantifying abnormal populations with absent or dim GPI-linked antigen expression.

 
 


 
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