Hematopathology

Stanford’s Hematopathology service offer expert hematopathology consultation on histologic slides, blocks, and fresh tissue samples, including blood and bone marrow.

The faculty members of Stanford’s Hematopathology service are nationally and internationally recognized experts who provide timely and accurate diagnoses for a variety of hematolymphoid neoplasms as well as benign disorders. They hold deep expertise in both anatomic and clinical pathology and are actively engaged in translational research efforts to define the molecular bases of lymphomas and leukemias and define novel diagnostic and prognostic biomarkers. Our services include:

Primary Diagnosis on Wet Tissue

Peripheral blood, bone marrow, and other fresh body fluid or tissue biopsy specimens may be submitted either for comprehensive evaluation or for pathologic diagnosis with specified ancillary studies including flow immunophenotyping, cytogenetic and molecular studies., When comprehensive evaluation of a case is requested, a Stanford hematopathologist will review the provided clinical history and slides to initiate the appropriate ancillary tests tailored to diagnostic and patient care needs, including flow cytometry, cytogenetics and/or molecular studies.

Flow Immunophenotyping

An optimal panel of antigens will be chosen under the guidance of a hematopathologist upon reviewing the clinical history and/or morphologic findings. Diagnostic flow cytometry immunophenotyping is available seven days a week and urgent results are quickly called to the ordering physician as a preliminary report. The Stanford Clinical Flow Cytometry Laboratory offers a comprehensive diagnostic test menu, including leukemia/lymphoma immunophenotyping, minimal residual disease monitoring assays, CD34+ stem cell quantitation, lymphocyte subset analysis, paroxysmal nocturnal hemoglobulinuria (PNH) screen, hereditary spherocytosis, and Sézary syndrome.

Slide Review Consult Cases

To submit slides for case review, please complete a Stanford requisition and include all slides, relevant reports, and related ancillary testing materials and reports.

If possible, please include a block, as it will greatly speed the finalization of the case should additional testing be necessary. Package all materials securely and send via a padded envelope.

Slide review consult materials should be shipped or delivered via courier to:

Stanford Hematopathology Service

Fresh Tissue Specimens, Peripheral Blood, Comprehensive Evaluations and Flow Cytometry

Please submit materials in proper transport media. All samples should be labeled with the patient information (name, DOB and one other unique identifier) and sealed in a biohazard bag. Please submit a signed Stanford requisition with each sample.

Proper specimen collection is vital to ensuring an accurate test result. Please refer to the individual test listing in the test directory for collection requirements.

Samples should be shipped or delivered via courier to:

Stanford Hematopathology Service
Attn: Specimen Processing
3375 Hillview Ave
Stanford, CA, 94304

Immunohistochemistry

Our immunohistochemistry laboratory offers a wide range of immunostains and in-situ hybridization assays.  Hematopathology consultants use these diagnostic procedures selectively, based on clinical and morphologic indications.

Molecular Pathology

We perform next generation sequencing studies for T- and B-cell clonality and hematolymphoid malignancy-associated somatic mutations,  and PCR for gene rearrangements.