Gastrointestinal & Hepatobiliary Pathology

Consultative Opinions & Case Reviews

Stanford’s Gastrointestinal & Hepatobiliary Pathology Service offers consultative opinions on challenging cases submitted from outside of the Stanford network. These consultations can be utilized to offer expert opinion, answer specific questions, perform corroborative studies for suspected or unusual disease entities, and to confirm diagnoses. This service includes assignment of a specialty pathology fellow to each case for individualized service. Call the dedicated GI service phone (650-885-0313) for questions.

• Complete mapping of gastric cancer in CDH1 germline mutation carriers
• Second read on all dysplasia diagnoses
• CAP templates on all malignancies
• MMR, PDL-1, HER2 IHC and EBV ISH on all gastric cancers
• MMR, PDL-1, HER2 IHC on all esophageal cancers
• MMR on all GI and hepatobiliary malignancies
• Reflex MLH1 promoter methylation on all MLH1/PMS2 deficient colorectal cancers
• HER2 IHC on all metastatic/recurrent colorectal cancers
• Reflex HER2 FISH for all equivocal HER2 IHC

All specimens and additional paperwork must be labeled with:

• A minimum of 2 patient identifiers (first and last name, date of birth, medical record number, pathology case ID)
• Specimen type and anatomic site

Consult Cases

To submit slides for case review, the following materials are required:

1. Fully completed Stanford Anatomic Pathology requisition form, including the requesting provider’s full name and NPI.
2. Pathology report (final or preliminary).
3. Glass slides and/or FFPE block.
4. Ancillary testing results or materials.
5. Patient demographics (name, DOB, address, phone), so Epic Care Everywhere can be activated, if applicable.

For cases with paraffin-embedded tissue, providing unstained slides or the paraffin block will expedite the work-up for ancillary studies.

Fresh/Fixed Tissue Specimens

To submit fresh/fixed tissue for processing and review, the following materials are required:

1. Fully completed Stanford Anatomic Pathology requisition form, including the requesting provider’s full name and NPI.
2. Patient demographics (name, DOB, address, phone), so Epic Care Everywhere can be activated, if applicable.
3. Submit specimen in proper transport media and seal container closed. See Test Directory for specimen collection instructions and stability information.

Immunohistochemistry

Our immunohistochemistry laboratory offers a wide array of antibody-based tests and in situ hybridization assays, which our pathologists select and interpret judiciously to refine their diagnoses.

These assays are validated for paraffin-embedded tissue, including cytology cell blocks. We provide testing for inflammatory myofibroblast tumor (ALK), MMR deficiency, pancreatic acinar cell carcinoma, and SDH deficiency, in addition to all the standard markers in gastrointestinal and hepatobiliary pathology (p53, p16, PDL-1, HER2, etc.). We also offer high-risk HPV in-situ hybridization.