Gastrointestinal & Hepatobiliary Pathology
A Subspecialty Of Anatomic Pathology
About Gastrointestinal & Hepatobiliary Pathology
Digestive diseases affect 1 in 5 Americans annually – at least 60 million people in the United States each year. Digestive diseases and colonoscopies account for nearly 75 million endoscopic diagnostic procedures across the US annually. The Gastrointestinal & Hepatobiliary Pathology service at Stanford provides comprehensive diagnostic expertise and services relating to the pathology of disorders of the gastrointestinal tract, liver, and pancreas.
Our Services
Submit a Specimen
Our Faculty
Ancillary Testing
Stanford’s Gastrointestinal & Hepatobiliary Pathology Service offers expert diagnosis for wet tissue and consult cases for neoplastic and non-neoplastic diseases of the gastrointestinal tract, liver, biliary tract, and pancreas. Our faculty has expertise in a wide spectrum of clinical specialties, including Barrett’s esophagus, celiac disease, inflammatory bowel disease, and premalignant dysplastic lesions and malignant lesions of the luminal gastrointestinal tract, pancreas, liver, and biliary tract.
Consultative Opinions & Case Reviews
Stanford’s Gastrointestinal & Hepatobiliary Pathology Service offers consultative opinions on challenging cases submitted from outside of the Stanford network. These consultations can be utilized to offer expert opinion, answer specific questions, perform corroborative studies for suspected or unusual disease entities, and to confirm diagnoses. This service includes assignment of a specialty pathology fellow to each case for individualized service.
Primary Pathology Diagnosis
Stanford’s Gastrointestinal & Hepatobiliary Pathology Service performs gross and microscopic examination and reporting of wet tissue cases. This includes:
- Complete mapping of gastric cancer in CDH1 germline mutation carriers
- Second read on all dysplasia diagnoses
- CAP templates on all malignancies
- MMR, PDL-1, HER2 IHC and EBV ISH on all gastric cancers
- MMR, PDL-1, HER2 IHC on all esophageal cancers
- MMR on all GI and hepatobiliary malignancies
- Reflex BRAF on all MLH1/PMS2 deficient colorectal cancers
- HER2 IHC on all metastatic/recurrent colorectal cancers
- Reflex HER2 FISH for all equivocal HER2 IHC
- CD117, ANO1 (DOG1), and SDHB (gastric) on all suspected GISTs
- P16 and when indicated, high-risk HPV ISH on squamous cell carcinoma
- Chromogranin, synaptophysin, INSM1 and Ki-67 on neuroendocrine tumors
- P53 and RB1 on suspected neuroendocrine carcinoma
- Diagnostic tests for pancreatic tumors, including beta-catenin, chymotrypsin, inhibin, etc.
- Diagnostic tests for liver adenomas
Consult Cases
To submit slides for case review, please fill out a Stanford requisition and include all slides, relevant reports, and ancillary testing materials and reports. If possible, please include a block, as it will greatly speed the finalization of the case should additional testing be necessary. Package all materials securely and send via a padded envelope.
Wet Tissue Specimens
Please submit materials in proper transport media. All samples should be labeled with the patient information (name, DOB and one other unique identifier) and sealed in a biohazard bag. Please submit a signed Stanford requisition with each sample.
Samples should be shipped or delivered via courier to:
Stanford Anatomic Pathology
Attn: Gastrointestinal & Hepatobiliary Pathology
300 Pasteur Drive, Room H2110
Stanford, CA 94305
Phone: 650-723-7211
Fax (650) 725-7409
New Client Inquiries
To arrange to be set up as a new client, please contact:
ClinOpsContracts@stanfordhealthcare.org.
Contact Us
To submit a specimen to Gastrointestinal Pathology, please complete a requisition and send with sample to:
Stanford Gastrointestinal & Hepatobiliary Pathology Service
300 Pasteur Drive, Room H2110
Stanford, CA 94305
Phone: 650-723-7211
Fax (650) 725-7409
gipathology@
stanfordhealthcare.org
Do not send patient info to this email.
Medical Director:
Teri Longacre, MD
To arrange to be set up as a new client, please contact:
ClinOpsContracts@
stanfordhealthcare.org
SAMPLE SUBMISSION LOGISTICS
For more information on submitting cases, see the links below:
All Requisitions
Download Stanford Requisitions for specimen submission.
Account Set-up
Information on personalized requisitions, supplies, shipping and courier pick-up.
Pricing Inquiries
Pricing inquiries and contract information.
Billing
Billing policies, information and questions.
Results Web Portal
Request access or log-in to our client results portal.
Specimen Collection and Handling
Specifications for Specimen Collection and Handling.
Consult Service FAQ's
Get answers to Frequently Asked Questions.
Teri A. Longacre, MD
APPOINTMENTS
- Professor of Pathology, Emerita Kempson Endowed Chair in Surgical Pathology
- Director, Gastrointestinal & Hepatobiliary Pathology Service
- Director, Gastrointestinal & Hepatobiliary Pathology Fellowship
- Director, Gynecologic Pathology Service
- Director, Gynecological Pathology Fellowship
PRACTICE AREAS
- Anatomic and Clinical Pathology
- Gastrointestinal & Hepatobiliary Pathology
- Gynecologic Pathology
- Soft Tissue Pathology
CONTACT
Email: longacre@stanford.edu
Phone: (650) 498-6460
More information about Teri Longacre:
https://med.stanford.edu/profiles/teri-longacre
https://profiles.stanford.edu/teri-longacre
Gerald J. Berry, MD
APPOINTMENTS
- Professor of Pathology
- Director of Anatomic Pathology
PRACTICE AREAS
- Pathology and Laboratory Medicine
- Anatomic Pathology
CONTACT
Email: gerald.berry@stanford.edu
Phone: (650) 498-4987
More information about Gerald Berry:
https://med.stanford.edu/profiles/gerald-berry
https://profiles.stanford.edu/gerald-berry
David Bingham, MD
APPOINTMENTS
- Clinical Assistant Professor, Pathology
PRACTICE AREAS
- Anatomic and Clinical Pathology
- Gastrointestinal Diseases
CONTACT
Phone: (650) 498-4391
More information about David Bingham:
https://med.stanford.edu/profiles/david-bingham
https://profiles.stanford.edu/david-bingham
Gregory Charville, MD, PhD
APPOINTMENTS
- Associate Professor of Pathology (Surgical Pathology)
- Medical Director, Soft Tissue and Bone Pathology Service
PRACTICE AREAS
- Bone-Soft Tissue Pathology
- Gastrointestinal-Hepatopancreatobiliary Pathology
- Anatomic Pathology
CONTACT
Email: gwc@stanford.edu
Phone: (650) 723-7211
More information about Gregory Charville:
https://med.stanford.edu/profiles/greg-charville
https://profiles.stanford.edu/greg-charville
John Higgins, MD
APPOINTMENTS
- Residency Program Director for Anatomic and Clinical Pathology
- Professor of Pathology
- Co-Director, Post-Sophomore Fellowship in Pathology
PRACTICE AREAS
- Liver Pathology
- GI Pathology
- Renal Pathology
- Transplant Pathology
- Pathology and Laboratory Medicine
- Anatomic and Clinical Pathology
CONTACT
Email: john.higgins@stanford.edu
Phone: (650) 723-7211
More information about John Higgins:
https://med.stanford.edu/profiles/john-higgins
https://profiles.stanford.edu/john-higgins
Jeanne Shen, MD
APPOINTMENTS
- Assistant Professor of Pathology (Gastrointestinal Pathology)
PRACTICE AREAS
- Anatomic and Clinical Pathology
- Gastrointestinal Pathology
- Pancreatobiliary Pathology
- Digital Pathology
CONTACT
Phone: (650) 723-7211
More information about Jeanne Shen:
https://med.stanford.edu/profiles/jeanne-shen
https://profiles.stanford.edu/jeanne-shen
Ancillary Testing
Stanford’s Gastrointestinal & Hepatobiliary Pathology Service relies on a suite of ancillary testing offerings to support our expert diagnosis. Learn more about these offerings. Many of these techniques, such as molecular profiling and cytogenetics, can be performed on cytology as well as tissue sections.
Immunohistochemistry
Our immunohistochemistry laboratory offers a wide array of antibody-based tests and in situ hybridization assays, which our pathologists select and interpret judiciously to refine their diagnoses.
These assays are validated for paraffin-embedded tissue, including cytology cell blocks. We provide testing for inflammatory myofibroblast tumor (ALK), MMR deficiency, pancreatic acinar cell carcinoma, and SDH deficiency, in addition to all the standard markers in gastrointestinal and hepatobiliary pathology (p53, p16, PDL-1, HER2, etc.). We also offer high-risk HPV in-situ hybridization.
Molecular Pathology
Molecular assays can be used for both diagnostic and prognostic purposes as well as for selection of targeted therapies. Stanford’s Solid Tumor Actionable Mutation Panel (STAMP) is validated on cytology specimens and paraffin-embedded tissue. We provide specific tests for various gastrointestinal mesenchymal lesions, including NTRK-rearranged sarcoma.
Cytogenetics
Cytogenetic studies are used to assess for chromosomal rearrangements in selected cases.
Stanford’s Gastrointestinal & Hepatobiliary Pathology Service offers expert diagnosis for wet tissue and consult cases for neoplastic and non-neoplastic diseases of the gastrointestinal tract, liver, biliary tract, and pancreas. Our faculty has expertise in a wide spectrum of clinical specialties, including Barrett’s esophagus, celiac disease, inflammatory bowel disease, and premalignant dysplastic lesions and malignant lesions of the luminal gastrointestinal tract, pancreas, liver, and biliary tract.
Consultative Opinions & Case Reviews
Stanford’s Gastrointestinal & Hepatobiliary Pathology Service offers consultative opinions on challenging cases submitted from outside of the Stanford network. These consultations can be utilized to offer expert opinion, answer specific questions, perform corroborative studies for suspected or unusual disease entities, and to confirm diagnoses. This service includes assignment of a specialty pathology fellow to each case for individualized service.
Primary Pathology Diagnosis
Stanford’s Gastrointestinal & Hepatobiliary Pathology Service performs gross and microscopic examination and reporting of wet tissue cases. This includes:
- Complete mapping of gastric cancer in CDH1 germline mutation carriers
- Second read on all dysplasia diagnoses
- CAP templates on all malignancies
- MMR, PDL-1, HER2 IHC and EBV ISH on all gastric cancers
- MMR, PDL-1, HER2 IHC on all esophageal cancers
- MMR on all GI and hepatobiliary malignancies
- Reflex BRAF on all MLH1/PMS2 deficient colorectal cancers
- HER2 IHC on all metastatic/recurrent colorectal cancers
- Reflex HER2 FISH for all equivocal HER2 IHC
- CD117, ANO1 (DOG1), and SDHB (gastric) on all suspected GISTs
- P16 and when indicated, high-risk HPV ISH on squamous cell carcinoma
- Chromogranin, synaptophysin, INSM1 and Ki-67 on neuroendocrine tumors
- P53 and RB1 on suspected neuroendocrine carcinoma
- Diagnostic tests for pancreatic tumors, including beta-catenin, chymotrypsin, inhibin, etc.
- Diagnostic tests for liver adenomas
close Our Services
Consult Cases
To submit slides for case review, please fill out a Stanford requisition and include all slides, relevant reports, and ancillary testing materials and reports. If possible, please include a block, as it will greatly speed the finalization of the case should additional testing be necessary. Package all materials securely and send via a padded envelope.
Wet Tissue Specimens
Please submit materials in proper transport media. All samples should be labeled with the patient information (name, DOB and one other unique identifier) and sealed in a biohazard bag. Please submit a signed Stanford requisition with each sample.
Samples should be shipped or delivered via courier to:
Stanford Anatomic Pathology
Attn: Gastrointestinal & Hepatobiliary Pathology
300 Pasteur Drive, Room H2110
Stanford, CA 94305
Phone: 650-723-7211
Fax (650) 725-7409
New Client Inquiries
To arrange to be set up as a new client, please contact:
ClinOpsContracts@stanfordhealthcare.org.
Contact Us
To submit a specimen to Gastrointestinal Pathology, please complete a requisition and send with sample to:
Stanford Gastrointestinal & Hepatobiliary Pathology Service
300 Pasteur Drive, Room H2110
Stanford, CA 94305
Phone: 650-723-7211
Fax (650) 725-7409
gipathology@
stanfordhealthcare.org
Do not send patient info to this email.
Medical Director:
Teri Longacre, MD
To arrange to be set up as a new client, please contact:
ClinOpsContracts@
stanfordhealthcare.org
SAMPLE SUBMISSION LOGISTICS
For more information on submitting cases, see the links below:
All Requisitions
Download Stanford Requisitions for specimen submission.
Account Set-up
Information on personalized requisitions, supplies, shipping and courier pick-up.
Pricing Inquiries
Pricing inquiries and contract information.
Billing
Billing policies, information and questions.
Results Web Portal
Request access or log-in to our client results portal.
Specimen Collection and Handling
Specifications for Specimen Collection and Handling.
Consult Service FAQ's
Get answers to Frequently Asked Questions.
close Submit a Specimen
Teri A. Longacre, MD
APPOINTMENTS
- Professor of Pathology, Emerita Kempson Endowed Chair in Surgical Pathology
- Director, Gastrointestinal & Hepatobiliary Pathology Service
- Director, Gastrointestinal & Hepatobiliary Pathology Fellowship
- Director, Gynecologic Pathology Service
- Director, Gynecological Pathology Fellowship
PRACTICE AREAS
- Anatomic and Clinical Pathology
- Gastrointestinal & Hepatobiliary Pathology
- Gynecologic Pathology
- Soft Tissue Pathology
CONTACT
Email: longacre@stanford.edu
Phone: (650) 498-6460
More information about Teri Longacre:
https://med.stanford.edu/profiles/teri-longacre
https://profiles.stanford.edu/teri-longacre
Gerald J. Berry, MD
APPOINTMENTS
- Professor of Pathology
- Director of Anatomic Pathology
PRACTICE AREAS
- Pathology and Laboratory Medicine
- Anatomic Pathology
CONTACT
Email: gerald.berry@stanford.edu
Phone: (650) 498-4987
More information about Gerald Berry:
https://med.stanford.edu/profiles/gerald-berry
https://profiles.stanford.edu/gerald-berry
David Bingham, MD
APPOINTMENTS
- Clinical Assistant Professor, Pathology
PRACTICE AREAS
- Anatomic and Clinical Pathology
- Gastrointestinal Diseases
CONTACT
Phone: (650) 498-4391
More information about David Bingham:
https://med.stanford.edu/profiles/david-bingham
https://profiles.stanford.edu/david-bingham
Gregory Charville, MD, PhD
APPOINTMENTS
- Associate Professor of Pathology (Surgical Pathology)
- Medical Director, Soft Tissue and Bone Pathology Service
PRACTICE AREAS
- Bone-Soft Tissue Pathology
- Gastrointestinal-Hepatopancreatobiliary Pathology
- Anatomic Pathology
CONTACT
Email: gwc@stanford.edu
Phone: (650) 723-7211
More information about Gregory Charville:
https://med.stanford.edu/profiles/greg-charville
https://profiles.stanford.edu/greg-charville
John Higgins, MD
APPOINTMENTS
- Residency Program Director for Anatomic and Clinical Pathology
- Professor of Pathology
- Co-Director, Post-Sophomore Fellowship in Pathology
PRACTICE AREAS
- Liver Pathology
- GI Pathology
- Renal Pathology
- Transplant Pathology
- Pathology and Laboratory Medicine
- Anatomic and Clinical Pathology
CONTACT
Email: john.higgins@stanford.edu
Phone: (650) 723-7211
More information about John Higgins:
https://med.stanford.edu/profiles/john-higgins
https://profiles.stanford.edu/john-higgins
Jeanne Shen, MD
APPOINTMENTS
- Assistant Professor of Pathology (Gastrointestinal Pathology)
PRACTICE AREAS
- Anatomic and Clinical Pathology
- Gastrointestinal Pathology
- Pancreatobiliary Pathology
- Digital Pathology
CONTACT
Phone: (650) 723-7211
More information about Jeanne Shen:
https://med.stanford.edu/profiles/jeanne-shen
https://profiles.stanford.edu/jeanne-shen
close Our Faculty
Ancillary Testing
Stanford’s Gastrointestinal & Hepatobiliary Pathology Service relies on a suite of ancillary testing offerings to support our expert diagnosis. Learn more about these offerings. Many of these techniques, such as molecular profiling and cytogenetics, can be performed on cytology as well as tissue sections.
Immunohistochemistry
Our immunohistochemistry laboratory offers a wide array of antibody-based tests and in situ hybridization assays, which our pathologists select and interpret judiciously to refine their diagnoses.
These assays are validated for paraffin-embedded tissue, including cytology cell blocks. We provide testing for inflammatory myofibroblast tumor (ALK), MMR deficiency, pancreatic acinar cell carcinoma, and SDH deficiency, in addition to all the standard markers in gastrointestinal and hepatobiliary pathology (p53, p16, PDL-1, HER2, etc.). We also offer high-risk HPV in-situ hybridization.
Molecular Pathology
Molecular assays can be used for both diagnostic and prognostic purposes as well as for selection of targeted therapies. Stanford’s Solid Tumor Actionable Mutation Panel (STAMP) is validated on cytology specimens and paraffin-embedded tissue. We provide specific tests for various gastrointestinal mesenchymal lesions, including NTRK-rearranged sarcoma.
Cytogenetics
Cytogenetic studies are used to assess for chromosomal rearrangements in selected cases.
close Ancillary Testing
Residencies and Fellowships
Anatomic Pathology Residency Programs
Stanford Pathology offers a 3-year anatomic pathology residency and 4-year combination residencies in anatomic pathology/clinical pathology and anatomic pathology/neuropathology.Stanford Pathology offers a 3-year anatomic pathology residency and 4-year combination residencies in anatomic pathology/clinical pathology and anatomic pathology/neuropathology.
Gastrointestinal Pathology Fellowships
Stanford offers an ACGME-accredited fellowship in Gastrointestinal Pathology.