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Molecular Genetic Pathology

A Subspecialty Of  Molecular Pathology & Genomics

About Molecular Genetic Pathology

Many genetic diseases and types of cancer result from the mutation of a single gene or a specific chromosomal rearrangement. Understanding which genes have changed allows clinicians to treat these specific genetic diseases or in the case of cancerous tumors, to provide therapies and treatments that directly target these changes. Stanford’s Molecular Genetic Pathology lab specializes in identifying these changes, setting the cornerstone of the patient’s treatment plan.

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Testing

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Our Faculty

 

Stanford Medicine’s Molecular Genetic Pathology Laboratory provides a comprehensive range of diagnostic services encompassing inherited genetic disorders, hematolymphoid malignancies, solid tumors, and genetic risk factors through meticulous analysis of nucleic acids (DNA and/or RNA).

Our next generation sequencing based assays provide molecular analysis for solid tumors and hematologic malignancies, facilitating comprehensive genome profiling for targeted therapies. Our in-house developed testing focuses on identifying clinically significant somatic mutations, offering actionable information for diagnosis, prognostic assessment, patient risk stratification, and eligibility for clinical trials.

Our panels include:

Solid Tumors (STAMP)

The Stanford Actionable Mutation Panel (STAMP) is a multigene NGS-based test that targets genes specifically selected for their known impact as actionable targets of existing or emerging anti-cancer therapies, their prognostic features, or for their mutation recurrence frequency in patients with known cancer types. The sequencing and analysis are performed in-house, and every case is reviewed by our pathologists who deliver a personalized interpretation based on each unique patient.

More Information

 

Hematopoietic and Lymphoid Neoplasms (Heme-STAMP)

Heme-STAMP is a multigene NGS-based test that detects single nucleotide variants (SNVs), short insertions and deletions, and selected gene rearrangements in genes recurrently altered in myeloid and lymphoid neoplasms.

More Information
 

B Cell and T Cell Clonality

These tests utilize next generation sequencing to characterize clonal rearrangements in B-Cells and T-Cells, aiding in the diagnosis of leukemias and lymphomas, including tracking of molecular residual disease (MRD).

More Information:

B cell clonality

Immunoglobulin somatic hypermutation

T cell clonality

T cell clonality MRD

Gene Fusion Events (Fusion-STAMP)

Fusion-STAMP is a multigene NGS-based test that detects potentially clinically actionable gene fusion events at the RNA level in genes implicated in cancer, targeting transcript isoforms.

More Information

 

Targeted Solid Tumor Assays

We offer a wide range of discrete testing to inform therapeutic treatment, including mutations in POLE, KRAS, EGFR, NRAS, IDH, IDH2, KIT, and BRAF. Test methodologies include single base primer extension (SnapShot) and target-specific PCR.

 

Molecular Hematopathology Services

We offer a range of molecular hematopathology services including testing for coagulation disorders, next generation sequencing for leukemias and lymphomas, and testing for individual markers including Calreticulin.

 

Test Directory

Learn more about our Molecular Genetic Pathology testing.

Find a test

California Newborn Screening Program

In addition to providing testing for patients and external clients, Stanford’s Molecular Genetic Pathology Laboratory is the exclusive diagnostic provider for the California Newborn Screening Program for the follow-up testing of cystic fibrosis and biotinidase deficiency.

Residencies and Fellowships

Clinical Pathology Residency Programs

Stanford Pathology offers Clinical Pathology residencies as well as a combination Anatomic Pathology/Clinical Pathology Residency.

 

At Stanford Medicine, we strive to deliver cutting-edge molecular genetic pathology services. If you have any inquiries or require further information, please do not hesitate to contact us.

Sample Submission

All specimens must be accompanied by a Stanford requisition and all samples must be labeled with the patient’s name, and at least one other unique identifier.

Proper specimen collection is vital to ensuring an accurate test result. A fasting specimen is preferred or required for many laboratory tests to reduce possible test interference. Please refer to the individual test listing in the Test Directory for fasting requirements collection requirements.

 

Shipping

Samples should be shipped or delivered via courier to:

Stanford Clinical Laboratories
Attn: Specimen Processing

3375 Hillview Avenue
Palo Alto, CA 94304

Customer Service Phone: 1-877-717-3733

 

Molecular Pathology Requisition

 

New Client Inquiries

To arrange to be set up as a new client, please contact:
ClinOpsContracts@stanfordhealthcare.org.

 

Contact Us

To submit a sample to Molecular Genetic Pathology, please complete a requisition and send with sample to:

Stanford Clinical Laboratories
Attn: Specimen Processing
3375 Hillview Avenue
Palo Alto, CA 94304

Customer Service Phone:
1-877-717-3733

molecularpathology@stanfordhealthcare.org
Do not send patient info to this email.

Medical Director:
Carlos Suarez, MD

To arrange to be set up as a new client, please contact:
ClinOpsContracts@stanfordhealthcare.org

Download Molecular Genetic Pathology Requisition

Contact Us

To submit a sample to Molecular Genetic Pathology, please complete a requisition and send with sample to:

 

Stanford Clinical Laboratories
Attn: Specimen Processing

3375 Hillview Avenue
Palo Alto, CA 94304

Customer Service Phone:
1-877-717-3733

molecularpathology@
stanfordhealthcare.org

Do not send patient info to this email.

Medical Director:
James L. Zehnder, MD

 

To arrange to be set up as a new client, please contact:
ClinOpsContracts@
stanfordhealthcare.org

 

Download Molecular Genetic Pathology Requisition

SAMPLE SUBMISSION LOGISTICS
For more information on submitting cases, see the links below:

All Requisitions
Download Stanford Requisitions for specimen submission.

Account Set-up
Information on personalized requisitions, supplies, shipping and courier pick-up.

Pricing Inquiries
Pricing inquiries and contract information.

Billing
Billing policies, information and questions.

Results Web Portal
Request access or log-in to our client results portal.

Specimen Collection and Handling
Specifications for Specimen Collection and Handling.

Consult Service FAQ's
Get answers to Frequently Asked Questions.

Carlos Jose Suarez, MD, MS

Carlos Suarez, MD

APPOINTMENTS

  • Molecular Pathologist
  • Clinical Associate Professor of Pathology, Stanford University School of Medicine
  • Co-Director, Genetic and Genomic Testing Consult Service
  • Director, Molecular Genetic Pathology Laboratory

PRACTICE AREAS

  • Anatomic Pathology
  • Clinical Pathology
  • Molecular Genetic Pathology

CONTACT

Email: cjsuarez@stanford.edu

More information about Carlos Suarez:
https://med.stanford.edu/profiles/carlos-jose-suarez
https://profiles.stanford.edu/carlos-jose-suarez

James L. Zehnder, MD

James L. Zehnder, MD

APPOINTMENTS

  • Professor of Pathology and Medicine (Hematology)
  • Director, Coagulation Laboratory

PRACTICE AREAS

  • Cancer > Hematology
  • Hematology
  • Pathology
  • Pathology and Laboratory Medicine

CONTACT

Email: zehnder@stanford.edu
Phone: 650-723-9232

More information about James Zehnder:
https://med.stanford.edu/profiles/james-zehnder
https://profiles.stanford.edu/james-zehnder

Fei Dong, MD

Fei Dong, MD

APPOINTMENTS

  • Associate Professor of Pathology
  • Associate Director, Molecular Genetic Pathology Laboratory

PRACTICE AREAS

  • Anatomic Pathology
  • Molecular Pathology

CONTACT

More information about Fei Dong:
https://med.stanford.edu/profiles/fei-dong

https://profiles.stanford.edu/fei-dong

Christian Kunder, MD, PhD

Christian Kunder, MD, PhD

APPOINTMENTS

  • Clinical Associate Professor of Pathology (Surgical Pathology and Molecular Genetics Pathology)

PRACTICE AREAS

  • Anatomic Pathology
  • Surgical Pathology
  • Urological Pathology
  • Soft Tissue Pathology
  • Molecular Pathology

CONTACT

More information about Christian Kunder:
https://med.stanford.edu/profiles/christian-kunder
https://profiles.stanford.edu/christian-kunder

Wei Gu

Wei Gu

APPOINTMENTS

  • Assistant Professor of Pathology

PRACTICE AREAS

  • Molecular Genetic Pathology

CONTACT

More information about Wei Gu:

https://med.stanford.edu/profiles/wei-gu

https://profiles.stanford.edu/wei-gu

Bing Melody Zhang, MD

Bing (Melody) Zhang, MD

APPOINTMENTS

  • Clinical Associate Professor of Pathology
  • Co-Director, Histocompatibility and Immunogenetics Laboratory

PRACTICE AREAS

  • Clinical Pathology
  • Molecular Genetic Pathology
  • Histocompatibility
  • Immunogenetics

CONTACT

Email: mbzhang@stanford.edu

More information about Bing Melody Zhang:
https://med.stanford.edu/profiles/Bing%20Zhang
https://stanfordbloodcenter.org/leadership/bing-melody-zhang/

Henning Stehr

Henning Stehr

APPOINTMENTS

  • Clinical Assistant Professor of Pathology
  • Director, Cancer bioinformatics (Molecular Genetic Pathology Laboratory)

PRACTICE AREAS

  • Molecular Genetic Pathology

CONTACT

Email: stehr@stanford.edu

More information about Henning Stehr:
https://profiles.stanford.edu/stehr 

Testing

Stanford Medicine’s Molecular Genetic Pathology Laboratory provides a comprehensive range of diagnostic services encompassing inherited genetic disorders, hematolymphoid malignancies, solid tumors, and genetic risk factors through meticulous analysis of nucleic acids (DNA and/or RNA).

Our next generation sequencing based assays provide molecular analysis for solid tumors and hematologic malignancies, facilitating comprehensive genome profiling for targeted therapies. Our in-house developed testing focuses on identifying clinically significant somatic mutations, offering actionable information for diagnosis, prognostic assessment, patient risk stratification, and eligibility for clinical trials.

Our panels include:

Solid Tumors (STAMP)

The Stanford Actionable Mutation Panel (STAMP) is a multigene NGS-based test that targets genes specifically selected for their known impact as actionable targets of existing or emerging anti-cancer therapies, their prognostic features, or for their mutation recurrence frequency in patients with known cancer types. The sequencing and analysis are performed in-house, and every case is reviewed by our pathologists who deliver a personalized interpretation based on each unique patient.

More Information

 

Hematopoietic and Lymphoid Neoplasms (Heme-STAMP)

Heme-STAMP is a multigene NGS-based test that detects single nucleotide variants (SNVs), short insertions and deletions, and selected gene rearrangements in genes recurrently altered in myeloid and lymphoid neoplasms.

More Information
 

B Cell and T Cell Clonality

These tests utilize next generation sequencing to characterize clonal rearrangements in B-Cells and T-Cells, aiding in the diagnosis of leukemias and lymphomas, including tracking of molecular residual disease (MRD).

More Information:

B cell clonality

Immunoglobulin somatic hypermutation

T cell clonality

T cell clonality MRD

Gene Fusion Events (Fusion-STAMP)

Fusion-STAMP is a multigene NGS-based test that detects potentially clinically actionable gene fusion events at the RNA level in genes implicated in cancer, targeting transcript isoforms.

More Information

 

Targeted Solid Tumor Assays

We offer a wide range of discrete testing to inform therapeutic treatment, including mutations in POLE, KRAS, EGFR, NRAS, IDH, IDH2, KIT, and BRAF. Test methodologies include single base primer extension (SnapShot) and target-specific PCR.

 

Molecular Hematopathology Services

We offer a range of molecular hematopathology services including testing for coagulation disorders, next generation sequencing for leukemias and lymphomas, and testing for individual markers including Calreticulin.

 

Test Directory

Learn more about our Molecular Genetic Pathology testing.

Find a test

California Newborn Screening Program

In addition to providing testing for patients and external clients, Stanford’s Molecular Genetic Pathology Laboratory is the exclusive diagnostic provider for the California Newborn Screening Program for the follow-up testing of cystic fibrosis and biotinidase deficiency.

Residencies and Fellowships

Clinical Pathology Residency Programs

Stanford Pathology offers Clinical Pathology residencies as well as a combination Anatomic Pathology/Clinical Pathology Residency.

 

At Stanford Medicine, we strive to deliver cutting-edge molecular genetic pathology services. If you have any inquiries or require further information, please do not hesitate to contact us.


close Testing
Submit a Sample

Sample Submission

All specimens must be accompanied by a Stanford requisition and all samples must be labeled with the patient’s name, and at least one other unique identifier.

Proper specimen collection is vital to ensuring an accurate test result. A fasting specimen is preferred or required for many laboratory tests to reduce possible test interference. Please refer to the individual test listing in the Test Directory for fasting requirements collection requirements.

 

Shipping

Samples should be shipped or delivered via courier to:

Stanford Clinical Laboratories
Attn: Specimen Processing

3375 Hillview Avenue
Palo Alto, CA 94304

Customer Service Phone: 1-877-717-3733

 

Molecular Pathology Requisition

 

New Client Inquiries

To arrange to be set up as a new client, please contact:
ClinOpsContracts@stanfordhealthcare.org.

 

Contact Us

To submit a sample to Molecular Genetic Pathology, please complete a requisition and send with sample to:

Stanford Clinical Laboratories
Attn: Specimen Processing
3375 Hillview Avenue
Palo Alto, CA 94304

Customer Service Phone:
1-877-717-3733

molecularpathology@stanfordhealthcare.org
Do not send patient info to this email.

Medical Director:
Carlos Suarez, MD

To arrange to be set up as a new client, please contact:
ClinOpsContracts@stanfordhealthcare.org

Download Molecular Genetic Pathology Requisition

Contact Us

To submit a sample to Molecular Genetic Pathology, please complete a requisition and send with sample to:

 

Stanford Clinical Laboratories
Attn: Specimen Processing

3375 Hillview Avenue
Palo Alto, CA 94304

Customer Service Phone:
1-877-717-3733

molecularpathology@
stanfordhealthcare.org

Do not send patient info to this email.

Medical Director:
James L. Zehnder, MD

 

To arrange to be set up as a new client, please contact:
ClinOpsContracts@
stanfordhealthcare.org

 

Download Molecular Genetic Pathology Requisition

SAMPLE SUBMISSION LOGISTICS
For more information on submitting cases, see the links below:

All Requisitions
Download Stanford Requisitions for specimen submission.

Account Set-up
Information on personalized requisitions, supplies, shipping and courier pick-up.

Pricing Inquiries
Pricing inquiries and contract information.

Billing
Billing policies, information and questions.

Results Web Portal
Request access or log-in to our client results portal.

Specimen Collection and Handling
Specifications for Specimen Collection and Handling.

Consult Service FAQ's
Get answers to Frequently Asked Questions.


close Submit a Sample
Our Faculty

Carlos Jose Suarez, MD, MS

Carlos Suarez, MD

APPOINTMENTS

  • Molecular Pathologist
  • Clinical Associate Professor of Pathology, Stanford University School of Medicine
  • Co-Director, Genetic and Genomic Testing Consult Service
  • Director, Molecular Genetic Pathology Laboratory

PRACTICE AREAS

  • Anatomic Pathology
  • Clinical Pathology
  • Molecular Genetic Pathology

CONTACT

Email: cjsuarez@stanford.edu

More information about Carlos Suarez:
https://med.stanford.edu/profiles/carlos-jose-suarez
https://profiles.stanford.edu/carlos-jose-suarez

James L. Zehnder, MD

James L. Zehnder, MD

APPOINTMENTS

  • Professor of Pathology and Medicine (Hematology)
  • Director, Coagulation Laboratory

PRACTICE AREAS

  • Cancer > Hematology
  • Hematology
  • Pathology
  • Pathology and Laboratory Medicine

CONTACT

Email: zehnder@stanford.edu
Phone: 650-723-9232

More information about James Zehnder:
https://med.stanford.edu/profiles/james-zehnder
https://profiles.stanford.edu/james-zehnder

Fei Dong, MD

Fei Dong, MD

APPOINTMENTS

  • Associate Professor of Pathology
  • Associate Director, Molecular Genetic Pathology Laboratory

PRACTICE AREAS

  • Anatomic Pathology
  • Molecular Pathology

CONTACT

More information about Fei Dong:
https://med.stanford.edu/profiles/fei-dong

https://profiles.stanford.edu/fei-dong

Christian Kunder, MD, PhD

Christian Kunder, MD, PhD

APPOINTMENTS

  • Clinical Associate Professor of Pathology (Surgical Pathology and Molecular Genetics Pathology)

PRACTICE AREAS

  • Anatomic Pathology
  • Surgical Pathology
  • Urological Pathology
  • Soft Tissue Pathology
  • Molecular Pathology

CONTACT

More information about Christian Kunder:
https://med.stanford.edu/profiles/christian-kunder
https://profiles.stanford.edu/christian-kunder

Wei Gu

Wei Gu

APPOINTMENTS

  • Assistant Professor of Pathology

PRACTICE AREAS

  • Molecular Genetic Pathology

CONTACT

More information about Wei Gu:

https://med.stanford.edu/profiles/wei-gu

https://profiles.stanford.edu/wei-gu

Bing Melody Zhang, MD

Bing (Melody) Zhang, MD

APPOINTMENTS

  • Clinical Associate Professor of Pathology
  • Co-Director, Histocompatibility and Immunogenetics Laboratory

PRACTICE AREAS

  • Clinical Pathology
  • Molecular Genetic Pathology
  • Histocompatibility
  • Immunogenetics

CONTACT

Email: mbzhang@stanford.edu

More information about Bing Melody Zhang:
https://med.stanford.edu/profiles/Bing%20Zhang
https://stanfordbloodcenter.org/leadership/bing-melody-zhang/

Henning Stehr

Henning Stehr

APPOINTMENTS

  • Clinical Assistant Professor of Pathology
  • Director, Cancer bioinformatics (Molecular Genetic Pathology Laboratory)

PRACTICE AREAS

  • Molecular Genetic Pathology

CONTACT

Email: stehr@stanford.edu

More information about Henning Stehr:
https://profiles.stanford.edu/stehr 


close Our Faculty

California Newborn Screening Program

In addition to providing testing for patients and external clients, Stanford’s Molecular Genetic Pathology Laboratory is the exclusive diagnostic provider for the California Newborn Screening Program for the follow-up testing of cystic fibrosis and biotinidase deficiency.

Residencies and Fellowships

Clinical Pathology Residency Programs

Stanford Pathology offers Clinical Pathology residencies as well as a combination Anatomic Pathology/Clinical Pathology Residency.

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